Bedbugs look for food at night. They bite while people or animals are sleeping. The bites are most often painless. Many people never know they've been bitten. But some people develop an itchy red welt or swelling. And if a person has an allergic reaction, severe itching, blisters, or hives can develop. Bites are often on areas that are exposed, such as the head, neck, arms, and hands. Bedbug bites aren't dangerous and don't spread illness. But if the bite is scratched and the skin is broken and irritated, there's a chance that a skin infection can develop.