The use of L-tryptophan has been linked with a condition that can be fatal. This is called eosinophilic myositis. It is also called eosinophilia-myalgia (EMS). The cause of the condition has been debated. Most experts doubt that L-tryptophan itself caused the problem. Instead, they think it may have been caused by something else in the compound.
Ongoing studies have found that 4,5-tryptophan-dione is likely at fault for this problem. In a study of over-the-counter L-tryptophan, this chemical was found to make up 0.5% to 10.3% of the samples of L-tryptophan. The FDA has allowed the sale of L-tryptophan since 2005. But you should use L-tryptophan only under the direction of a doctor.
If you have diabetes, talk with your doctor before using L-tryptophan.
People who are pregnant or breastfeeding should talk with a doctor before taking any herbal or dietary supplements.
Don't take L-tryptophan if you take any of these medicines:
- Antidepressants/anxiolytics (tricyclics, SSRIs)
- Monoamine oxidase inhibitors (MAOIs)
- Benzodiazepines
- Barbiturates
- Linezolid
- Carbidopa