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    Citrulline

    Other name(s):

    a-amino-d-ureido-n-valeric acid

    Unsubstantiated claims

    There may be benefits that have not yet been proven through research.

    Citrulline is a nonessential amino acid. It removes ammonia from your body. It may also stimulate the immune system and boost energy levels. Early studies show that citrulline doesn’t help exercise performance. It may reduce neutrophilia. It may also improve symptoms in people with sickle cell disease. Further research is needed to determine if citrulline is helpful in these conditions.

    Recommended intake

    Amino acids (AAs) can be taken as single AAs or in AA combinations. They also come as part of multivitamins, proteins, and food supplements. The forms include tablets, fluids, and powders.

    If you eat enough protein in your diet, you get all of the amino acids you need.

    There are no conditions that increase how much citrulline you need.

    Side effects, toxicity, and interaction

    Using a single amino acid supplement may lead to negative nitrogen balance. This can lessen how well your metabolism works. It can also make your kidneys work harder. In children, taking single amino acid supplements may also cause growth problems.

    You should not take high doses of single amino acids for long periods of time.

    Women who are pregnant or breastfeeding should not take citrulline supplements.

    Online Medical Reviewer: Bianca Garilli MD
    Online Medical Reviewer: Chris Southard RN
    Online Medical Reviewer: Jessica Gotwals RN BSN MPH
    Date Last Reviewed: 8/1/2023
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    Southern New Mexico
    Surgery Center

    2301 Indian Wells Rd. Suite B
    Alamogordo, NM 88310
    www.snmsc.org

    Phone: 575.437.0890
    Fax: 575.437.0905
    Email: info@snmsc.org

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